The final programme is listed below and can also be downloaded in a pdf-format here.


The list of posters can be downloaded here.


The conference dinner will take place at BLOX and coach will leave from Rigshospitalet and Kong Arthur Hotel.




(Status 08-10-2018)



WEDNESDAY 24 October 2018


12.30 – 13.15: Registration and sandwich lunch


13.15 Welcome: Ewa Rajpert-De Meyts


13.30 – 15.15: Pathology and epidemiology of testicular germ cell cancer

Chairpersons: Wolter Oosterhuis and Katherine McGlynn


13.30. Daniel Berney (London, UK): What is new in the latest WHO classification of testicular tumours and what else needs to be changed.


14.00. Andreas Stang (Essen, Germany): Incidence of testicular cancer in Germany according to WHO. (short presentation).


14.15. Ariana Znaor (Lyon, France): Predicting the testicular cancer incidence burden in Europe to 2035


14.45. Jason K. Gurney (Wellington, New Zealand): Unexpected features of the epidemiology of testicular cancer among different populations in New Zealand


15.15-15.45 Coffee/tea break


15.45 – 17.15: Genetic predisposition to testicular germ cell tumours

Chairpersons: Peter Kanetsky and Rolf Skotheim


15.45. Katherine McGlynn (Bethesda, MD, USA): International trends in the incidence of testicular cancer: are we close to an explanation of ethnic differences?


16.15. Kate Nathanson (Philadelphia, PA, USA): Novel testicular cancer predisposition loci begin to reveal possible mechanisms.


16.45. Maria Santa Rocca (Padua, Italy): Association between copy number variations and risk of testicular cancer.


17.15 - 17.30 Short break


17.30 - 19.00: Developmental pathways implicated in the pathogenesis of human germ cell malignancy

Chairpersons: Kate Loveland and Jason Heaney


17.30. Walfred Tang (Cambridge, UK): Epigenetic dysregulation of primordial germ cells and gonocytes as a mechanism of transformation to germ cell neoplasia in situ


18.00. Anne Jørgensen (Copenhagen, DK): The involvement of NODAL/Activin pathway in testicular dysgenesis and dysregulation of pluripotency in human fetal germ cells.


18.30. Rod Mitchell (Edinburgh, UK): Modelling endocrine disruption and disorders of sex development in human fetal testis.


19.00 - 21.00 Welcome reception




THURSDAY 25 October 2018


09.00 – 10.30: Disruption of meiosis in the pathogenesis of germ cell cancer

Chairpersons: Anne Jørgensen and Jim Amatruda


9.00. Ramsay J. McFarlane (Bangor, Wales, UK): Meiosis-like functions in oncogenesis.


9.30. Aspasia Ploubidou (Jena, Germany): Spindle misorientation in the aetiology of male hypofertility, intratubular germ cell neoplasia and seminoma.


10.00. Anne Goriely (Oxford, UK): Spermatocytic tumours: what can this rare TGCT teach us about the fundamental processes operating in the adult male germline?

10.30 - 11.00 Coffee/tea break

11.00 - 13.00: Animal models and novel pathways implicated in the pathogenesis of germ cell cancer

Chairpersons: Rod Mitchell and Walfred Tang


11.00. Jason Heaney (Houston, TX, USA): Developmental origins and genetic risk factors of testicular germ cell tumors in mice.


11.30. Robert S. Weiss (New York, NY, USA): A mouse model of malignant testicular cancer based on KRAS activation and PTEN inactivation.


12.00. Joanna Selfe (London, UK): IGF1R signalling in primordial germ cells and testicular cancer.


12.30. Trine B. Haugen (Oslo, Norway): SPRY4 and SPRY4-IT1 as possible oncogenes in TGCT



13.00 - 14.45: POSTER SESSION and lunch

(The list of posters can be downloaded here)



14.45 - 16.30: Genomic and epigenetic changes in germ cell tumours

Chairpersons: Kristian Almstrup and Kate Nathanson


14.45. Hubert Schorle (Bonn, Germany): The plasticity of germ cell cancer and its dependence on the cellular microenvironment.


15.30. Leendert H. Looijenga (Rotterdam, the Netherlands): Clinical relevance of (epi)genetic changes during reprograming of GCNIS/seminoma to nonseminomas.


16.00. Louise Pyle (Philadelphia, PA, USA): Genomic changes in testicular germ cell tumors revealed by genome sequencing.


16.30. Chey Loveday (Sutton, UK): Large-scale exome sequencing study of TGCT patients and controls. (short presentation).


16.45 - 17.15 Coffee/tea break


17.15 - 18.15: Immunological aspects of testicular germ cell tumours

Chairpersons: Ewa Rajpert-De Meyts and Jonathan Shamash


17.15. Kate Loveland (Clayton, VIC, Australia): The contributions of cytokines to immune cell identities and functions in testicular germ cell tumours.


17.45. Michal Chovanec (Bratislava, Slovakia): Immune mechanisms and possible immune therapy in testicular germ cell tumours.


FRIDAY 26 October 2018


8.45 - 10.00: Paediatric germ cell tumours: special risk groups, genomics and management

Chairpersons: Jenny Poynter and Louisa Pyle


8.45. Ewa Rajpert-De Meyts (Copenhagen, Denmark): Risk of germ cell neoplasia in sex chromosome aneuploidy.


9.00. Leendert Looijenga (Rotterdam, the Netherlands): Risk of germ cell cancer in the androgen insensitivity syndrome.


9.20. James Amatruda (Dallas, TX, USA): Genomics of paediatric germ cell tumours.


9.50. Lindsay Frazier (Boston, MA, USA): The Malignant Germ Cell International Consortium: Breaking down barriers to design the clinical and scientific agenda for pediatric and adolescent/young adult GCT patients.


10.20 - 10.45 Coffee break

10.45 - 12.35: Diagnosis of GCNIS and risk classification of overt tumours

Chairpersons: Leendert Looijenga and Carsten Bokemeyer


10.45. Kristian Almstrup (Copenhagen, DK): Detection of GCNIS in semen samples – the past, the present and the future.


11.05. Klaus-Peter Dieckmann (Hamburg, Germany): Detection of GCNIS using specific miRNA profiles.


11.35. Gedske Daugaard (Copenhagen, DK): Risk factors predicting relapse of stage I testicular cancer undergoing surveillance.


12.00. Joerg Beyer (Bern, Switzerland): Risk classification in patients with disseminated disease.


12.30. Solveig Abildtrup Larsen (Aarhus, DK): MRI with DW imaging for follow-up of patients treated for TC stage 1. (short presentation).



12.45 - 13.45: POSTER SESSION and lunch

(The list of posters can be downloaded here)



13.45 - 15.30: Management of testicular cancer resistant to treatment

Chairpersons: Gedske Daugaard and Jörg Beyer


13.45. Robert Hamilton (Toronto, Canada): Surgical treatment of disseminated GCTs – what is new and why?

14.15. Carsten Bokemeyer (Hamburg, Germany): Clinical features and current treatment of refractory germ cell tumours.


14.45. Christoph Oing (Hamburg, Germany): Molecular basis of treatment resistance and potential therapeutic targets.


15.15 - 15.45 Coffee break


15.45 - 17.30: Management of late effects in testicular cancer survivors

Chairpersons: Niels Jørgensen and Mikael Rørth


15.45. Jourik A. Gietema (Groningen, the Netherlands): Genetic susceptibility to late effects of chemotherapy in TGCT survivors.


16.15. Mikkel Bandak (Copenhagen, DK): Testosterone deficiency in testicular cancer survivors – current evidence and future directions.


16.35. Jakob Lauritsen (Copenhagen, DK): Risk of cardiovascular disease in long-term survivors of testicular cancer.


16.55. Michael Kreiberg (Copenhagen, DK): Quality of life in long-term survivors of testicular cancer

17.20. Concluding remarks and closure.




Conference Dinner at BLOX (19.00-24.00)

Coaches for the dinner will leave from

Rigshospitalet and Kong Arthur Hotel at 18.30

Arrival at BLOX at ~19.00



SATURDAY 27 October 2018


9.00 – 13.00 Testicular Cancer Consortium (TECAC) meeting

(for registered members only)