The conference dinner will take place at BLOX and coach will leave from Rigshospitalet and Kong Arthur Hotel.
12.30 – 13.15: Registration and sandwich lunch
13.15 Welcome: Ewa Rajpert-De Meyts
13.30 – 15.15: Pathology and epidemiology of testicular germ cell cancer
Chairpersons: Wolter Oosterhuis and Katherine McGlynn
13.30. Daniel Berney (London, UK): What is new in the latest WHO classification of testicular tumours and what else needs to be changed.
14.00. Andreas Stang (Essen, Germany): Incidence of testicular cancer in Germany according to WHO. (short presentation).
14.15. Ariana Znaor (Lyon, France): Predicting the testicular cancer incidence burden in Europe to 2035
14.45. Jason K. Gurney (Wellington, New Zealand): Unexpected features of the epidemiology of testicular cancer among different populations in New Zealand
15.15-15.45 Coffee/tea break
15.45 – 17.15: Genetic predisposition to testicular germ cell tumours
Chairpersons: Peter Kanetsky and Rolf Skotheim
15.45. Katherine McGlynn (Bethesda, MD, USA): International trends in the incidence of testicular cancer: are we close to an explanation of ethnic differences?
16.15. Kate Nathanson (Philadelphia, PA, USA): Novel testicular cancer predisposition loci begin to reveal possible mechanisms.
16.45. Maria Santa Rocca (Padua, Italy): Association between copy number variations and risk of testicular cancer.
17.15 - 17.30 Short break
17.30 - 19.00: Developmental pathways implicated in the pathogenesis of human germ cell malignancy
Chairpersons: Kate Loveland and Jason Heaney
17.30. Walfred Tang (Cambridge, UK): Epigenetic dysregulation of primordial germ cells and gonocytes as a mechanism of transformation to germ cell neoplasia in situ
18.00. Anne Jørgensen (Copenhagen, DK): The involvement of NODAL/Activin pathway in testicular dysgenesis and dysregulation of pluripotency in human fetal germ cells.
18.30. Rod Mitchell (Edinburgh, UK): Modelling endocrine disruption and disorders of sex development in human fetal testis.
19.00 - 21.00 Welcome reception
09.00 – 10.30: Disruption of meiosis in the pathogenesis of germ cell cancer
Chairpersons: Anne Jørgensen and Jim Amatruda
9.00. Ramsay J. McFarlane (Bangor, Wales, UK): Meiosis-like functions in oncogenesis.
9.30. Aspasia Ploubidou (Jena, Germany): Spindle misorientation in the aetiology of male hypofertility, intratubular germ cell neoplasia and seminoma.
10.00. Anne Goriely (Oxford, UK): Spermatocytic tumours: what can this rare TGCT teach us about the fundamental processes operating in the adult male germline?
10.30 - 11.00 Coffee/tea break
11.00 - 13.00: Animal models and novel pathways implicated in the pathogenesis of germ cell cancer
Chairpersons: Rod Mitchell and Walfred Tang
11.00. Jason Heaney (Houston, TX, USA): Developmental origins and genetic risk factors of testicular germ cell tumors in mice.
11.30. Robert S. Weiss (New York, NY, USA): A mouse model of malignant testicular cancer based on KRAS activation and PTEN inactivation.
12.00. Joanna Selfe (London, UK): IGF1R signalling in primordial germ cells and testicular cancer.
12.30. Trine B. Haugen (Oslo, Norway): SPRY4 and SPRY4-IT1 as possible oncogenes in TGCT
14.45 - 16.30: Genomic and epigenetic changes in germ cell tumours
Chairpersons: Kristian Almstrup and Kate Nathanson
14.45. Hubert Schorle (Bonn, Germany): The plasticity of germ cell cancer and its dependence on the cellular microenvironment.
15.30. Leendert H. Looijenga (Rotterdam, the Netherlands): Clinical relevance of (epi)genetic changes during reprograming of GCNIS/seminoma to nonseminomas.
16.00. Louise Pyle (Philadelphia, PA, USA): Genomic changes in testicular germ cell tumors revealed by genome sequencing.
16.30. Chey Loveday (Sutton, UK): Large-scale exome sequencing study of TGCT patients and controls. (short presentation).
16.45 - 17.15 Coffee/tea break
17.15 - 18.15: Immunological aspects of testicular germ cell tumours
Chairpersons: Ewa Rajpert-De Meyts and Jonathan Shamash
17.15. Kate Loveland (Clayton, VIC, Australia): The contributions of cytokines to immune cell identities and functions in testicular germ cell tumours.
17.45. Michal Chovanec (Bratislava, Slovakia): Immune mechanisms and possible immune therapy in testicular germ cell tumours.
8.45 - 10.00: Paediatric germ cell tumours: special risk groups, genomics and management
Chairpersons: Jenny Poynter and Louisa Pyle
8.45. Ewa Rajpert-De Meyts (Copenhagen, Denmark): Risk of germ cell neoplasia in sex chromosome aneuploidy.
9.00. Leendert Looijenga (Rotterdam, the Netherlands): Risk of germ cell cancer in the androgen insensitivity syndrome.
9.20. James Amatruda (Dallas, TX, USA): Genomics of paediatric germ cell tumours.
9.50. Lindsay Frazier (Boston, MA, USA): The Malignant Germ Cell International Consortium: Breaking down barriers to design the clinical and scientific agenda for pediatric and adolescent/young adult GCT patients.
10.20 - 10.45 Coffee break
10.45 - 12.35: Diagnosis of GCNIS and risk classification of overt tumours
Chairpersons: Leendert Looijenga and Carsten Bokemeyer
10.45. Kristian Almstrup (Copenhagen, DK): Detection of GCNIS in semen samples – the past, the present and the future.
11.05. Klaus-Peter Dieckmann (Hamburg, Germany): Detection of GCNIS using specific miRNA profiles.
11.35. Gedske Daugaard (Copenhagen, DK): Risk factors predicting relapse of stage I testicular cancer undergoing surveillance.
12.00. Joerg Beyer (Bern, Switzerland): Risk classification in patients with disseminated disease.
12.30. Solveig Abildtrup Larsen (Aarhus, DK): MRI with DW imaging for follow-up of patients treated for TC stage 1. (short presentation).
13.45 - 15.30: Management of testicular cancer resistant to treatment
Chairpersons: Gedske Daugaard and Jörg Beyer
13.45. Robert Hamilton (Toronto, Canada): Surgical treatment of disseminated GCTs – what is new and why?
14.15. Carsten Bokemeyer (Hamburg, Germany): Clinical features and current treatment of refractory germ cell tumours.
14.45. Christoph Oing (Hamburg, Germany): Molecular basis of treatment resistance and potential therapeutic targets.
15.15 - 15.45 Coffee break
15.45 - 17.30: Management of late effects in testicular cancer survivors
Chairpersons: Niels Jørgensen and Mikael Rørth
15.45. Jourik A. Gietema (Groningen, the Netherlands): Genetic susceptibility to late effects of chemotherapy in TGCT survivors.
16.15. Mikkel Bandak (Copenhagen, DK): Testosterone deficiency in testicular cancer survivors – current evidence and future directions.
16.35. Jakob Lauritsen (Copenhagen, DK): Risk of cardiovascular disease in long-term survivors of testicular cancer.
16.55. Michael Kreiberg (Copenhagen, DK): Quality of life in long-term survivors of testicular cancer
17.20. Concluding remarks and closure.
Conference Dinner at BLOX (19.00-24.00)
Coaches for the dinner will leave from
Rigshospitalet and Kong Arthur Hotel at 18.30
Arrival at BLOX at ~19.00
9.00 – 13.00 Testicular Cancer Consortium (TECAC) meeting
(for registered members only)